Destin, a 2016 star at Tampa Bay Downs, beat Infobedad by a length in Friday's $200,000 Marathon (Grade 2) at Del Mar.
The race was 1 3/4 miles on dirt, and was not part of the Breeders' Cup. It had been a Breeders' Cup race for several years.
John Velazquez rode the 4-year-old Destin for trainer Todd Pletcher.
Last year, Destin won both the Sam F. Davis (Grade 3) and the Tampa Bay Derby (Grade 2) at Tanpa Bay Downs,. He later finished second by a nose to Creator in the Belmont Stakes (Grade 1).